Dinler Antunes is a Postdoctoral Research Associate at the Computer Science Department of Rice University (Houston, TX), interested in structural bioinformatics and immunology. He is working with structural prediction of peptide-MHC (pMHC) complexes, with applications on cellular immune response and vaccine development. He is developing new docking-based methods to predict binding modes of large peptides to MHC-I receptors, aiming to explore MHC allotypes with special biomedical interest. He is also using molecular dynamics in collaborative projects to study conformational changes of other proteins of the immune system.
He attained his BS degree in Biomedicine at the Federal University of Rio Grande do Sul (Brazil) in 2008, and received a MS in Genetics and Molecular Biology from the same University in 2011. During his PhD, concluded in 2014, he applied bioinformatics tools to identify molecular features responsible for complex immunological phenomena, such as heterologous immunity. His work has shown in silico predictions of T cell cross-reactivity among viral epitopes, which were later confirmed by in vitro experiments. He was involved in the development of a curate repository of pMHC structures, focused on immunogenicity and cross-reactivity prediction (CrossTope), and is also a monthly contributor of the Brazilian Society of Immunology Blog (SBlogI).
Contact: “dinler”at rice.edu